PTPN1 monoclonal antibody, clone 107AT531
产品名称： PTPN1 monoclonal antibody, clone 107AT531
英文名称： PTPN1 monoclonal antibody, clone 107AT531
产品编号： MAB1152
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against partial recombinant PTPN1.
- Immunogen:
- Recombinant protein corresponding to amino acids 1-321 of human PTPN1.
- Host:
- Mouse
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Isotype:
- IgG1
- Storage Buffer:
- In ascites (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- PTPIP51 in Protein Interactions: Regulation and In Situ Interacting Partners.
Brobeil A, Bobrich M, Tag C, Wimmer M.Cell Biochem Biophys. 2012 Apr 28.
- 2.
- Interaction of PTPIP51 with Tubulin, CGI-99 and Nuf2 During Cell Cycle Progression.
Brobeil A, Grafe M, Eiber M, Wimmer M.Biomolecules 2012, 2(1), 122-142
- 3.
- PTPIP51 is phosphorylated by Lyn and c-Src kinases lacking dephosphorylation by PTP1B in acute myeloid leukemia.
Brobeil A, Bobrich M, Graf M, Kruchten A, Blau W, Rummel M, Oeschger S, Steger K, Wimmer M.Leuk Res. 2011 Apr 20. [Epub ahead of print]
- 4.
- PTPIP51-a myeloid lineage specific protein interacts with PTP1B in neutrophil granulocytes.
Brobeil A, Graf M, Oeschger S, Steger K, Wimmer M.Blood Cells Mol Dis. 2010 Jun 1. [Epub ahead of print]
- Entrez GeneID:
- 5770
- Protein Accession#:
- P18031
- Gene Name:
- PTPN1
- Gene Alias:
- PTP1B
- Gene Description:
- protein tyrosine phosphatase, non-receptor type 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq
- Other Designations:
- OTTHUMP00000031266,non-receptor tyrosine phosphatase 1,protein tyrosine phosphatase 1B,protein tyrosine phosphatase, placental
- Gene Pathway
- Related Disease
- Albuminuria
- Alzheimer Disease
- Alzheimer disease
- Arteriosclerosis
- Atherosclerosis
- Atherosclerosis
- Atrophy
- Calcinosis
- Cardiomyopathy, Hypertrophic
- Cardiovascular Diseases
- Cerebrovascular Disorders
- Coronary Artery Disease
- Coronary Disease
- Diabetes Complications
- Diabetes Mellitus
- Diabetes Mellitus, Type 2
- Diabetic Angiopathies
- Diabetic Retinopathy
- Dyslipidemias