Size  100ul
Cat code  220029
Species Cross-reactivity  H, M
Key Application  WB
Host  Mouse
Clone Number  1F12-C3
Antibody type  Monoclonal antibody
Purified method  
Isotype  IgG1
Molecular Weight  115kDa
Sensitivity  The antibody detects endogenous level of BMPR2 protein.
Immunogen  Purified recombinant fragment of human BMPR2 expressed in E. Coli.
UniProt Number  Q13873
GeneBank ID  NM_001204
Subcellular location  Membrane; Single-pass type I membrane protein.
Formulation  Ascitic fluid containing 0.03% sodium azide.
Altername  BMP type II receptor; BMP type-2 receptor; BMPR 2; BMPR 3; BMPR II; BMPR-2; BMPR-II; Bmpr2; BMPR2_HUMAN; BMPR3; BMPRII; BMR 2; BMR2; Bone morphogenetic protein receptor type 2; Bone morphogenetic protein receptor type II; Bone morphogenetic protein receptor type-2; Bone morphogenic protein receptor type II serine threonine kinase; BRK 3; BRK3; PPH 1; PPH1; Serine threonine kinase type II activin receptor like kinase; T ALK; TALK; Type II activin receptor like kinase;
Gene_symbol  BMR2; PPH1; BMPR3; BRK-3; T-ALK; BMPR-II
Summary  This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]
UniPort summary  Function  On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
Application Images :  
Western blot detection of BMPR2 antibody in COS7, Hela and 3T3 cell lysates using BMPR2 antibody (dilution 1:500).Predicted band size:115 KDa.Observed band size:115KDa.