Size  100ug
Cat code  200537
Species Cross-reactivity  R
Key Application  WB,ICC
Host  Mouse
Antibody type  Monoclonal antibody
Purified method  Affinity purified
Isotype  IgG1
Molecular Weight  42kDa
Sensitivity  This antibody detects endogenous levels AMACR(C-terminus) and does not cross-react with related proteins.
Immunogen  Purified recombinant human AMACR(C-terminus) protein fragments expressed in E.coli.
UniProt Number  Q9UHK6
GeneBank ID  NM_014324
Subcellular location  Peroxisome. Mitochondrion
Formulation  Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Altername  RM; RACE; CBAS4; AMACRD
Gene_symbol  RM; RACE; CBAS4; AMACRD
Summary  This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)-and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described.
UniPort summary  Function  Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers
Application Images :  
Western blot detection of AMACR(C-terminus) antibody in Rat Liver lysates using AMACR(C-terminus) antibody (1:1000 diluted).
Predicted band size: 42KDa
Observed band size: 42KDa.